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5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market size is estimated to reach $141 million by 2026, growing at a CAGR of 4.1% during the forecast period 2021-2026. 5-Aminolevulinic acid an endogenous non-proteinogenic amino acid, is the earliest compound in the porphyrin synthesis pathway, the pathway that results in heme in mammals, and chlorophyll in plants. Aminolevulinic acid HCl (5-aminolevulinic acid HCl; ALA) is a prodrug that is metabolized intracellularly to produce the photosensitizing molecule protoporphyrin (PpIX). The increasing application in photodynamic therapy and surgery of cancer is driving the growth of the 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs market. Actinic keratosis is a condition that brings about scaly patches on the skin from exposure to the sun over the years. Actinic keratosis is typically detected on the face, lips, ears, neck, back of the hand, and forearms. 5-aminolevulinic acid hydrochloride is utilized in conjunction with blue light illumination for the healing of minimally to moderately thick actinic keratosis of the face or scalp. Aminolevulinic Acid is a topically applied metabolic precursor of protoporphyrin IX, termed as porphyrin precursor. Sonodynamic therapy (SDT) consists of sonosensitizer, low-intensity ultrasound, and molecular oxygen. 5-aminolevulinic acid hydrochloride (ALA) is an efficient sonosensitizer for healing of cancer utilizing SDT, ALA-mediated SDT produced in vitro anti-tumor effect on pancreatic cancer cells. The heightening focus of research institutes and laboratories on the distribution of 5-aminolevulinic acid hydrochloride drugs through diverse technologies is set to propel the growth of the 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market during the forecast period 2021-2026. This represents the 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market Industry Outlook.
5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market Segment Analysis – By Delivery Type:
The 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market based on delivery type can be further segmented into Delivery By Mouth, Delivery By Skin, and Others. The Delivery By Skin Segment held the largest market share in 2020. This growth is owing to the increased application of 5-Aminolevulinic Acid Hydrochloride (ALA) drugs for the treatment of skin ailments like actinic keratosis where the use of 5-Aminolevulinic Acid is recommended in combination with photodynamic therapy, a special light healing technique. Once the medicine has been applied to the face or scalp, exposure to sunlight needs to be avoided for up to 48 hours. Furthermore, the Delivery by Mouth segment is estimated to grow with the fastest CAGR of 5.2% during the forecast period 2021-2026 owing to the increased availability and utilization of FDA (Food and Drug Administration) approved 5-Aminolevulinic Acid Hydrochloride (5-ALA HCl) for Oral Solution.
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5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market Segment Analysis – By Application:
The 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market based on the application can be further segmented into Cancer Diagnosis, Cancer treatment With PDT (photodynamic therapy), and Fluorescence Guided Surgery. The Cancer Diagnosis Segment held the largest market share in 2020. This growth is owing to the increasing count of cancer cases worldwide. As per World Health Organization (WHO), nearly 70% of fatalities from cancer happen in low- and middle-income countries. 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs can be utilized in the detection of cancer and this is driving the growth of this segment. Photodynamic therapy (PDT) is a healing technique that utilizes a medication termed photosensitizer or photosensitizing agent and a specific kind of light. When photosensitizers are exposed to a particular wavelength of light, they generate a kind of oxygen that destroys nearby cells. Furthermore, the Cancer treatment With PDT (photodynamic therapy) segment is estimated to grow with the fastest CAGR of 4.8% during the forecast period 2021-2026 owing to its increased application in treating ailments like actinic keratosis.
5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market Segment Analysis – By Geography:
The 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market based on geography can be further segmented into North America, Europe, Asia-Pacific, South America, and the Rest of the World. North America held the largest share with 33% of the overall market in 2020. The growth of this region is owing to the increasing count of cancer cases and early phase identification and healing of ailments which are fuelling the growth of the biotechnology and research sector. This is, in turn, propelling the progress of the 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market in the North American region. Furthermore, the Asia-Pacific region is estimated to be the region with the fastest growth over the forecast period 2021-2026. This growth is owing to factors like expanding population, altered lifestyles, increase in cancer awareness among patients, and an upsurge in per-capita spend. Furthermore, the accelerating economic progress in countries like India and China backs the healthcare framework and development of pharmaceutical firms and biotech laboratories is propelling the progress of the 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market in the North American region.
5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market Drivers
Global Prevalence of Cancerous Ailments Like Bladder Cancer Is Projected To Drive The Growth Of 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market:
As per the Centers For Disease Control And Prevention (CDC), nearly 56,000 men and 17,500 women are infected with bladder cancer, and nearly 12,000 men and 4,700 women lose their lives from the ailment every year in the U.S. Furthermore, as per CDC, the hazard of bladder cancer can be decreased by not smoking and being cautious around few chemicals. 5-Aminolevulinic Acid Hydrochloride (ALA) finds application in photodynamic therapy. 5-Aminolevulinic Acid Hydrochloride (ALA) can be utilized for the identification of bladder cancer. The increasing application of 5-Aminolevulinic Acid Hydrochloride (ALA) for the treatment of bladder cancer is fuelling the growth of the 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market during the forecast period 2021-2026.
Agricultural Application Of 5-ALA Is Expected To Boost The Demand Of The 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Industry:
Apart from its application in photodynamic therapy, 5-Aminolevulinic Acid Hydrochloride (ALA) is extensively utilized in the agricultural sector in the form of a novel kind of light-stimulated insecticide with high natural harmony and discrimination. Current investigations have demonstrated that 5-Aminolevulinic Acid Hydrochloride (ALA) has the ability to manage the synthesis of chlorophyll, enhance the balance of chlorophyll, and enhance photosynthetic effectiveness, advance photosynthesis, advance plant tissue differentiation, restrict breathing in the dark, augment the stomatal and additional elementary physiological activities. It is not just a biological metabolic intermediate product, but also participates in the management procedure of plant growth and development, has the identical physiological activity of plant hormones, It can be utilized as a plant growth regulator in agricultural production. Herbicides manufactured utilizing 5-ala HCL can destroy dicotyledons weeds, and do not harm crops like grains, wheat, and barley, which are a part of the monocot family, and have discriminating weed-control results. These determinants are propelling the growth of the 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market during the forecast period 2021-2026.
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5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market Challenges
Restrictions And Side-Effects Pertaining To The Usage Of 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Are Challenging the growth of the Market:
5-Aminolevulinic Acid Hydrochloride (ALA) is utilized in the treatment of actinic keratosis on the face and scalp. However, restrictions apply to the usage of 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs and hamper the growth of the 5-Aminolevulinic Acid like staying away from sunlight or bright indoor light for up to 48 hours consequent to the usage of this medication on the skin or scalp. One should not be treated with 5-Aminolevulinic Acid if one is allergic to it. The physician needs to be informed if there is a soybean allergy or porphyria or if one is pregnant or breastfeeding. Typical side effects may consist of pain, burning, redness, or swelling of treated skin; itching, stinging, tingling, or prickly feeling; scaling or crusting of the skin; headache; chills; or puffy eyelids. More serious side-effects may be inclusive of liver injury and nerve issues. Hyperthermia can happen too. Sometimes, it may be fatal too. These issues are challenging the growth of the 5-Aminolevulinic Acid Hydrochloride (ALA) market.
5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market Landscape:
Product launches, technological advancements, partnerships, and networks are key strategies adopted by players in the 5-Aminolevulinic Acid Hydrochloride (ALA) Drugs Market. The Key companies of this market include:
SBI Pharmaceuticals Co., Ltd
Chiracon GmbH
Biofrontera AG
Dusa Pharmaceuticals, Inc.
Zhengzhou Xinlian Chemical
Shaanxi Yongyuan Bio-Tech Co., Ltd.
An Yi Biotech
Nanjing Chemlin
NMT
Yian Biotech
Acquisitions/Product Launches:
In March 2021, Biofrontera AG, an international biopharmaceutical company, declared the submission for approval of a novel, significantly bigger red-light source for photodynamic therapy (PDT) to be utilized in conjunction with Ameluz®, the BF-RhodoLED® XL, to the U.S. Food and Drug Administration (FDA). The novel BF-RhodoLED® XL is to be approved in conjunction with Ameluz® for the healing of mild and moderate actinic keratoses on the face and scalp.
As per an update in August 2020, Yongyuan Bioorganic plant derivatives persist with good sales. The list of products include Reishi Mushroom extract, Astragalus Extract, White Kidney Bean extract, Genistein, Boswellia Extract, Schisandra Extract, Bitter melon Extract, Wheatgrass Extract, Cassia Seed Extract, Senna Leaf Extract, Kudzu Root Extract.
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Key Takeaways
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